O2 Library

Comparative Efficacy

Beliveau A, Boyne DJ, Slater J, Brenner DR, Arora P. BUGSnet: An R Package to Facilitate the Conduct and Reporting of Bayesian Network Meta-Analyses. BMC Medical Research Methododology. 2019;19(196).

Stone C, Mickle A, Boyne DJ, Mohamed A, Rabi D, Brenner DR, Friedenreich CM. Treatment for Lymphoma and Late Cardiovascular Disease Risk: A Systematic Review and Meta-analysis. Health Science Reports. 2019; 2(10), e135

Boyne DJ, Mickle AT, Brenner DR, Friedenreich CM. Rabi DM, The Long-Term Risk of Fatal Cardiovascular Disease among Lymphoma Survivors: A Systematic Review and Meta-Analysis. 2018. Cancer Medicine. 7 (9), 4801-4813.

Clinical Decision Support

Gupta A, Slater J, Mitsakakis N, Boyne D, Druzdzel M, Beliveau A, Brenner DR, Arora P. Bayesian Networks for estimating risk of coronary artery disease: Applications of a data-driven machine learning method. Medical Decision Making. 2019; Oct 16:2729.

Boyne DJ, O’Sullivan DE, Heer EV, Hilsden RJ, Sajobi TT, Cheung WY, Brenner DR, Friedenreich CM. Prognostic factors of adjuvant chemotherapy discontinuation among stage III colon cancer patients: A survey of medical oncologists and a systematic review and meta-analysis. Cancer Med. 2020 Mar;9(5):1613-1627. doi: 10.1002/cam4.2843. Epub 2020 Jan 21. PMID: 31962372

Health Economics

Sam D, Cheung WY. A population-level comparison of cancer-related and non-cancer-related health care costs using publicly available provincial administrative data. Curr Oncol. 2019 Apr; 26(2): 94-97.

Cheung WY, Kornelsen EA, Mittmann N, Leighl NB, Cheung M, Chan KK, Bradbury PA, Ng RCH, Chen BE, Ding K, Pater JL, Tu D, Hay AE. The economic impact of the transition from branded to generic oncology drugs. Curr Oncol. 2019 Apr; 26(2): 89-93.

Weymann D, Laskin J, Roscoe R, Schrader KA, Chia S, Yip S, Cheung WY, Gelmon KA, Karsan A, Renouf DJ, Marra M, Regier DA. The cost and cost trajectory of whole-genome analysis guiding treatment of patients with advanced cancers. Mol Genet Genomic Med. 2017 Mar 12; 5(3): 251-260.

De Oliveira C, Pataky R, Bremner KE, Rangrej J, Chan KK, Cheung WY, Hoch JS, Peacock S, Krahn MD. Estimating the Cost of Cancer Care in British Columbia and Ontario: A Canadian Inter-Provincial Comparison. Healthc Policy. 2017 Feb;12(3):95-108.

Brenner DR. Using Machine Learning to Bend the Cost Curve – Addressing High-Cost Targeted Therapeutics. JAMA Network Open. 2019;2(9):e1911913.


Brenner DR, Weir HK, Demers AA, Ellison LF, Louzado C, Shaw A, Turner D, Woods RR, Smith LM; Canadian Cancer Statistics Advisory Committee. Projected estimates of cancer in Canada in 2020. CMAJ. 2020 Mar 2;192(9):E199-E205. doi: 10.1503/cmaj.191292. Epub 2020 Mar 2. PMID: 32122974

Yong JH, Mainprize JG, Yaffe MJ, Ruan Y, Poirier AE, Coldman A, Nadeau C, Iragorri N, Hilsden RJ, Brenner DR. The impact of episodic screening interruption: COVID-19 and population-based cancer screening in Canada. J Med Screen. 2020 Nov 26:969141320974711. doi: 10.1177/0969141320974711. Online ahead of print. PMID: 33241760

Heer E, Ruan Y, Mealey N, Quan ML, Brenner DR. The incidence of breast cancer in Canada 1971-2015: trends in screening-eligible and young-onset age groups. Can J Public Health. 2020 Oct;111(5):787-793. doi: 10.17269/s41997-020-00305-6. Epub 2020 Mar 6. PMID: 32144720

Mealey NE, O’Sullivan DE, Pader J, Ruan Y, Wang E, Quan ML, Brenner DR. Mutational landscape differences between young-onset and older-onset breast cancer patients. BMC Cancer. 2020 Mar 12;20(1):212. doi: 10.1186/s12885-020-6684-z. PMID: 32164620

O’Sullivan DE, Hilsden RJ, Ruan Y, Forbes N, Heitman SJ, Brenner DR. The incidence of young-onset colorectal cancer in Canada continues to increase. Cancer Epidemiol. 2020 Dec; 69:101828. doi: 10.1016/j.canep.2020.101828. Epub 2020 Sep 28. PMID: 32998071

Forbes N, Hilsden RJ, Martel M, Ruan Y, Dube C, Rostom A, Shorr R, Menard C, Brenner DR, Barkun AN, Heitman SJ. Association Between Time to Colonoscopy After Positive Fecal Testing and Colorectal Cancer Outcomes: A Systematic Review. Clin Gastroenterol Hepatol. 2020 Oct 1:S1542-3565(20)31378-1. doi: 10.1016/j.cgh.2020.09.048. Online ahead of print. PMID: 33010414

Sutherland RL, Ormsbee J, Pader J, Forbes N, Town S, Hilsden RJ, Brenner DR. Vitamin D supplementation reduces the occurrence of colorectal polyps in high-latitude locations. Prev Med. 2020 Jun;135:106072. doi: 10.1016/j.ypmed.2020.106072. Epub 2020 Apr 1. PMID: 32247012

Hilsden RJ, Heitman SJ, Lamidi M, Diallo MD, English J, Town S, Cartwright S, Maxwell C, McGillivray ME, McGregor E, Barberio A, Pader J, Brenner D, Rabeneck L. Cohort profile: The Forzani & MacPhail Colon Cancer Screening Centre biorepository, Calgary, Alberta. BMJ Open. 2020 Nov 11;10(11):e038119. doi: 10.1136/bmjopen-2020-038119.PMID: 33177135

Forbes N, Boyne DJ, Mazurek MS, Hilsden RJ, Sutherland RL, Pader J, Ruan Y, Shaheen AA, Wong C, Lamidi M, Lorenzetti DL, Brenner DR, Heitman SJ. Association Between Endoscopist Annual Procedure Volume and Colonoscopy Quality: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2020 Sep;18(10):2192-2208.e12. doi: 10.1016/j.cgh.2020.03.046. Epub 2020 Mar 30. PMID: 32240836

O’Sullivan DE, Metcalfe A, Hillier TWR, King WD, Lee S, Pader J, Brenner DR. Combinations of modifiable lifestyle behaviours in relation to colorectal cancer risk in Alberta’s Tomorrow Project. Sci Rep. 2020 Nov 25;10(1):20561. doi: 10.1038/s41598-020-76294-w.PMID: 33239697

Batra A, Rigo R, Sheka D, Cheung WY. Real-world evidence on adjuvant chemotherapy in older adults with stage II/III colon cancer. World J Gastrointest Oncol. 2020 Jun 15;12(6):604-618. doi: 10.4251/wjgo.v12.i6.604.PMID: 32699576

Elegbede AA, Gibson AJ, Fu H, Dean ML, Ezeife DA, Lau H, Cheung WY, Bebb DG. Real-World Adherence to Guideline-Recommended Treatment for Small Cell Lung Cancer. Am J Clin Oncol. 2020 Apr;43(4):236-242. doi: 10.1097/COC.0000000000000657.PMID: 31842113

Hohmann NS, McDaniel CC, Mason SW, Cheung WY, Williams MS, Salvador C, Graves EK, Camp CN, Chou C. Patient perspectives on primary care and oncology care coordination in the context of multiple chronic conditions: A systematic review. Res Social Adm Pharm. 2020 Aug;16(8):1003-1016. doi: 10.1016/j.sapharm.2019.11.014. Epub 2019 Nov 26. PMID: 31812499

Batra A, Kong S, Cheung WY. Eligibility of real-world patients with metastatic breast cancer for clinical trials. Breast. 2020 Dec;54:171-178. doi: 10.1016/j.breast.2020.10.005. Epub 2020 Oct 17. PMID: 33120082

Singh N, Batra A, Yang L, Boyne DJ, Harper A, Ghatage P, Cuthbert CA, Cheung WY. Patient-Reported Symptom Burden Near the End of Life in Patients With Gynaecologic Cancers. J Obstet Gynaecol Can. 2021 Jan;43(1):26-33. doi: 10.1016/j.jogc.2020.06.017. Epub 2020 Jul 6. PMID: 32967796

Cuthbert CA, Xu Y, Kong S, Boyne DJ, Hemmelgarn BR, Cheung WY. Patient-level factors associated with chronic opioid use in cancer: a population-based cohort study. Support Care Cancer. 2020 Sep;28(9):4201-4209. doi: 10.1007/s00520-019-05224-y. Epub 2020 Jan 3. PMID: 31900614

Karim S, Cheung WY, Bu J, Jess E, Kerba M. Medical Cannabis Authorization in Patients With Cancer in the Prelegalization Era: A Population-Based Study. J Pain Symptom Manage. 2020 Jun;59(6):1223-1231. doi: 10.1016/j.jpainsymman.2019.12.367. Epub 2019 Dec 28. PMID: 31887404

Cuthbert CA, Boyne DJ, Yuan X, Hemmelgarn BR, Cheung WY. Patient-reported symptom burden and supportive care needs at cancer diagnosis: a retrospective cohort study. Support Care Cancer. 2020 Dec;28(12):5889-5899. doi: 10.1007/s00520-020-05415-y. Epub 2020 Apr 8. PMID: 32270311

Batra A, Kong S, Cheung WY. Eligibility of Real-World Patients With Stage II and III Colon Cancer for Adjuvant Chemotherapy Trials. Clin Colorectal Cancer. 2020 Dec;19(4):e226-e234. doi: 10.1016/j.clcc.2020.05.005. Epub 2020 May 26. PMID: 32636076

Hernandez-Torres C, Cheung WY, Kong S, O’Callaghan CJ, Hsu T. Accrual of older adults to cancer clinical trials led by the Canadian cancer trials group – Is trial design a barrier? J Geriatr Oncol. 2020 Apr;11(3):455-462. doi: 10.1016/j.jgo.2019.08.004. Epub 2019 Aug 28. PMID: 31473189

Outcomes Analysis

Suo A, Chan Y, Beaulieu C, Kong S, Cheung WY, Monzon JG, Smylie M, Walker J, Morris D, Cheng T. Anti-PD1-Induced Immune-Related Adverse Events and Survival Outcomes in Advanced Melanoma. Oncologist. 2020 May;25(5):438-446. doi: 10.1634/theoncologist.2019-0674. Epub 2020 Feb 12. PMID: 32048768

Boyne DJ, O’Sullivan DE, Heer EV, Hilsden RJ, Sajobi TT, Cheung WY, Brenner DR, Friedenreich CM. Prognostic factors of adjuvant chemotherapy discontinuation among stage III colon cancer patients: A survey of medical oncologists and a systematic review and meta-analysis. Cancer Med. 2020 Mar;9(5):1613-1627. doi: 10.1002/cam4.2843. Epub 2020 Jan 21. PMID: 31962372

Grünwald V, Chirovsky D, Cheung WY, Bertolini F, Ahn MJ, Yang MH, Castro G, Berrocal A, Sjoquist K, Kuyas H, Auclair V, Guillaume X, Joo S, Shah R, Harrington K; GLANCE H&N STUDY Investigators. Global treatment patterns and outcomes among patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results of the GLANCE H&N study. Oral Oncol. 2020 Mar;102:104526. doi: 10.1016/j.oraloncology.2019.104526. Epub 2020 Jan 21. PMID: 31978755

Batra A, Rigo R, Hannouf MB, Cheung WY. Real-world Safety and Efficacy of Raltitrexed in Patients With Metastatic Colorectal Cancer. Clin Colorectal Cancer. 2020 Sep 18:S1533-0028(20)30135-3. doi: 10.1016/j.clcc.2020.09.006. Online ahead of print. PMID: 33268287

Brandwein JM, Saini L, Geddes MN, Yusuf D, Liu F, Schwann K, Billawala A, Westcott C, Kurniawan JA, Cheung WY. Outcomes of patients with relapsed or refractory acute myeloid leukemia: a population-based real-world study. Am J Blood Res. 2020 Aug 25;10(4):124-133. eCollection 2020. PMID: 32923092

Arora RK, Gibson AW, Bebb DG, Cheung WY. The Population-based Impact of Adjuvant Chemotherapy on Outcomes in T2N0M0 Non-Small Cell Lung Cancer. Am J Clin Oncol. 2020 Jul;43(7):496-503. doi: 10.1097/COC.0000000000000694.PMID: 32349021

Pham TM, Quy PN, Horimatsu T, Muto M, Shack L, Cheung WY, Kubo T, Fujino Y, Matsuda S. Premature mortality due to stomach cancer in Japan: a nationwide analysis from 1980 to 2015. Ann Epidemiol. 2020 Jul;47:19-24. doi: 10.1016/j.annepidem.2020.05.012. Epub 2020 Jun 3. PMID: 32713503

Abraham AG, Usmani N, Warkentin B, Thai J, Yun J, Ghosh S, Cheung W, Xu Y, Nijjar T, Severin D, Tankel K, Fairchild A, Joseph K. Dosimetric Parameters Predicting Late Small Bowel Toxicity in Patients With Rectal Cancer Receiving Neoadjuvant Chemoradiation. Pract Radiat Oncol. 2021 Jan-Feb;11(1):e70-e79. doi: 10.1016/j.prro.2020.07.004. Epub 2020 Aug 7. PMID: 32771626

Batra A, Sheka D, Kong S, Cheung WY. Impact of pre-existing cardiovascular disease on treatment patterns and survival outcomes in patients with lung cancer. BMC Cancer. 2020 Oct 15;20(1):1004. doi: 10.1186/s12885-020-07487-9.PMID: 33059611

Boyne DJ, Brenner DR, Sajobi TT, Hilsden RJ, Yusuf D, Xu Y, Friedenreich CM, Cheung WY. Development of a Model for Predicting Early Discontinuation of Adjuvant Chemotherapy in Stage III Colon Cancer. JCO Clin Cancer Inform. 2020 Oct;4:972-984. doi: 10.1200/CCI.20.00065. PMID: 33125264

Ding PQ, Batra A, Xu Y, McKinnon GP, Cheung WY. Obesity and Its Impact on Outcomes in Patients With Stage III Colon Cancer Receiving Adjuvant Chemotherapy. Clin Colorectal Cancer. 2020 Sep;19(3):209-218. doi: 10.1016/j.clcc.2020.02.010. Epub 2020 Feb 26. PMID: 32291245

Atchison KM, Pham TM, Sikdar KC, Weeks LA, Karosas APV, Sinnarajah A, Dort JC, Cheung WY, Shack L. Premature deaths due to head and neck cancers in canada: A nationwide analysis from 1980 to 2010. Laryngoscope. 2020 Apr;130(4):911-917. doi: 10.1002/lary.28024. Epub 2019 Apr 25. PMID: 31021397

Bosma NA, Tilley D, Batra A, Cheung WY. Characterizing Urban-Rural Differences in Colon Cancer Outcomes: A Population-based Analysis Based on Travel Distance to Cancer Center. Am J Clin Oncol. 2020 Jul;43(7):531-535. doi: 10.1097/COC.0000000000000703. PMID: 32324599

Yusuf D, Walton RN, Hurry M, Farrer C, Bebb DG, Cheung WY. Population-based Treatment Patterns and Outcomes for Stage III Non-Small Cell Lung Cancer Patients: A Real-world Evidence Study. Am J Clin Oncol. 2020 Sep;43(9):615-620. doi: 10.1097/COC.0000000000000716. PMID: 32889830

Batra A, Yang L, Boyne DJ, Harper A, Cheung WY, Cuthbert CA. Associations between baseline symptom burden as assessed by patient-reported outcomes and overall survival of patients with metastatic cancer. Support Care Cancer. 2020 Jul 16. doi: 10.1007/s00520-020-05623-6. Online ahead of print. PMID: 32676854

Batra A, Yang L, Boyne DJ, Harper A, Cuthbert CA, Cheung WY. Symptom burden in patients with common cancers near end-of-life and its associations with clinical characteristics: a real-world study. Support Care Cancer. 2020 Oct 26. doi: 10.1007/s00520-020-05827-w. Online ahead of print. PMID: 33104922

Xu Y, Cuthbert CA, Karim S, Kong S, Dort JC, Quan ML, Hinther AV, Quan H, Hemmelgarn BR, Cheung WY. Associations Between Physician Prescribing Behavior and Persistent Postoperative Opioid Use Among Cancer Patients Undergoing Curative-intent Surgery: A Population-based Cohort Study. Ann Surg. 2020 May 8. doi: 10.1097/SLA.0000000000003938. Online ahead of print. PMID: 32398487

Batra A, McKinnon G, Billawala A, Sheka D, Kong S, Cheung WY. Factors associated with the initiation of chemotherapy within 90 days of death in metastatic colorectal cancer patients: a population-based study. Support Care Cancer. 2020 Jul 29. doi: 10.1007/s00520-020-05655-y. Online ahead of print. PMID: 32725376

Khaki AR, Xu Y, Cheung WY, Li L, Fedorenko C, Grivas P, Ramsey S, Shankaran V. Comparison of Health Care Utilization at the End of Life Among Patients With Cancer in Alberta, Canada, Versus Washington State. JCO Oncol Pract. 2020 Dec;16(12):e1543-e1552. doi: 10.1200/OP.20.00217. Epub 2020 Aug 17. PMID: 32804586

Machine Learning and Artificial Intelligence

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